Meet the Professor:
Gennady Rogatsky
Gennady Rogatsky is a Physiology Professor and a known scientist who has being involved in experimental studies of Hyperbaric Oxygen for the last 35 years of his scientific career.
Prof. Rogatsky speaks at national and international medical conferences. Respectable online publishers and journals published his papers.
After his recent retirement from the Life Science Faculty of Bar-Ilan University, Israel where he worked for the last 17 years, Prof. Rogatsky moved to Canada to join his children and continue his scientific activities.
Among Gennady's other passions are traveling, fishing and singing. He has an excellent bass, loves classical and choral music and keeps singing in a choir for many years.
Brief biography facts
Gennady Rogatsky, MD, PhD, DSc, Physiology Professor, born in 1936 in Gorkij city, Russia.
1954-1960: Md – Faculty of General Medicine, Nizhny Novgorod State Medical Academy, Russia.
1968: PhD – Pavlov Institute of Physiology, Academy of Science, St. Petersburg, Russia.
1960-1964: General Practitioner, Dept of Internal Medicine, City Hospital of Zhukovsky City, Russia.
1964-1969: Physician research Regional Research Clinical Institute, Moscow.
1969-1972: Research fellow, Institute of Transplantation, Academy of Medical Science, Moscow.
1972-1983: Sr. research scientist, Chief of the Chest Trauma Research Unit, Sklifosovsky Emergency Medicine Research Institute, Moscow.
1983: DSc - Medical Academy, Moscow, Russia.
1983-1990: Associate Professor, Sklifosovsky Emergency Medicine Research Institute, Moscow.
1991-2003: Sr. research scientist and Associate Professor, Faculty of Life Science, Bar Ilan University, Ramat Gan, Israel.
2003: Professor, Faculty of Life Science, Bar-Ilan University, Ramat Gan, Israel.
Scientific Papers written by Gennady Rogatsky on topics related to Hyperbaric Oxygenation
Below are abstracts of some papers written on the HBOT related topics. The PDF version of full papers will be available for the free download in the future....
The life-saving effect of hyperbaric oxygenation during early-phase severe blunt chest injuries.
Rogatsky G.G., Mayevsky A.
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
The effect of hyperbaric oxygenation (HBO2) on survival during the early phase of severe blunt chest injury (BChI) has not been elucidated. Our aim was to investigate this effect on human victims of BChI. We monitored cardiac index (CI), stroke volume index (SVI), PaO2 and PaO2/FiO2 in 18 victims treated conventionally, and 8 victims treated under combined conventional and HBO2 treatment. Out of the 18 victims, 4 survived (Group A) and 14 died (Group B). Another 8 victims, in Group C, received HBO, and all survived. Human victims showed marked reductions in all cardiorespiratory values during the first 24 h. Group B persistently tended towards a decrease in SVI, PaO2/FiO2 and PaO2, eventually reaching fatal levels. The survivors developed a cardiorespiratory function characterized by a tendency towards recovery of all monitored parameters, more notable in Group C, which showed an earlier and more significant normalization vs. Group A (P<0.01). Our clinical data suggest that the earliest possible HBO2 treatment after severe blunt trauma can significantly enhance victims' survival.
Acute Brain and Cardio-respiratory Dysfunction after Blast/Blunt Injuries: The Life preserving Effects of Hyperbaric Oxygenation.
Rogatsky G.G., Mayevsky A.
The Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel
Today there is an ever-growing necessity to use more aggressive and pathophysiologically adequate techniques of emergency and intensive care in the early stages of modern bombing/blast injuries. The purpose of this review is to present modern data regarding the pathophysiology of the early period of blast injury, focusing on the impairment of hemodynamic and respiration, mostly the role of acute cardio-respiratory and brain dysfunction in the pathogenesis of severe and critical conditions due to blast/blunt injuries. The literature analysis emphasizes the crucial role of early impairment of myocardial contractility in the pathogenesis and outcome of severe traumas established over the course of the last decade in experimental and clinical studies. This review presents the results of laboratory and clinical observations, evidencing the principally important, life-saving effects of the early application of hyperbaric oxygenation in order to correct life-threatening dysfunctions of vital organs (brain, heart, and lungs) resulting from trauma, and to prevent the development of such conditions when trauma consequences are less severe. Also, new data are presented on the possible mechanisms of hyperbaric oxygenation protective effects in cases of severe chest and head injuries. Based on the available literature, we consider the desirability of establishing and employing mobile hyperbaric oxygenation chambers in emergency hyperbaric medicine. Read the full article...
Optimal dosing as a necessary condition for the efficacy of Hyperbaric Oxygen Therapy in acute ischemic stroke:
A critical review.
Rogatsky G.G., Shifrin E.G., Mayevsky A.
Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel.
The effectiveness of Hyperbaric Oxygen Therapy (HBOT) in clinical and experimental acute ischemic stroke (AIS) has been controversial for many years. However, in the literature, no data was found on the dose/effect of HBOT in patients with AIS. We analyzed retrospectively the published data of clinical studies performed in different hyperbaric centers (a total of 265 patients). The dose of HBOT (DHBOT) was calculated considering the product intrabarochamber pO2 (ATA), the duration of a single HBOT exposure (hours), and the number of HBOT treatments. Efficacy of HBOT (EfHBOT) data regarding the number of patients who showed significant clinical improvement of their neurologic status in the course of the treatment HBOT (the percentage of the total number of patients). The level of EfHBOT in each study was compared with a corresponding value of DHBOT. A comparison of the data shows a pronounced tendency for higher values of EfHBOT as the level of the average values of the total DHBOT increases. The coefficient of correlation between these parameters appears to be fairly high (r = 0.92). The maximum possible value of EfHBOT is 100%, which corresponded to the average values of DHBOT at a level of no less than 30 agreed units. The examined data suggest that applying optimal total DHBOT may provide a maximum possible EfHBOT in treating patients with AIS.
Effect of hyperbaric oxygenation on intracranial pressure elevation rate in rats during the early phase of severe traumatic brain injury.
Rogatsky G.G., Kamenir Y., Mayevsky A.
Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO2) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO2 treatment has a therapeutic effect on ICP dynamics and survival following severe fluid percussion brain injury (FPBI) in rats. Changes in ICP level were analyzed every 30 min during an 8-h monitoring period following trauma and at the end of experiment (20 h). The control (A) and experimental (B) groups consisted of 7 and 4 rats, respectively. Group B was subjected to 1.5 atmospheres absolute (ATA) 100% oxygen for 60 min beginning 2 h after FPBI. No significant differences in ICP were noted between groups A and B before and after HBO2 treatment until 3.5 h after trauma. At 4 h, for the first time, the difference became significant (P = 0.025; n = 11) and remained significant (P < 0.05) for all measurement points until end of monitoring, when mean ICP values reached 37.17 ± 14.25 and 20.25 ± 2.63 mm Hg in groups A and B, respectively. Linear approximation models showed different trends (b1 = 3.80 ± 0.23; r2 = 0.65, P < 0.001 and b1 = 1.56 ± 0.25; r2 = 0.77, P < 0.001) for groups A and B, respectively. Covariance analysis confirmed significant differences between slopes for groups A and B (F = 148.04, P < 0.001; df = 2,177), i.e., a significant difference in mean rate of ICP elevation. By the end of the experiment, 3 out of 7 rats from group A had died, but none from group B. We conclude that the application of HBO2 during the early phase of severe FPBI significantly diminished ICP elevation rate and decreased mortality level.
Hyperbaric oxygenation affects rat brain function after carbon monoxide exposure.
Rogatsky G.G.1; Meilin S.1; Zarchin N.1; Thom S.R.2; Mayevsky A.1
1Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, ISRAEL2Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068, ETATS-UNIS
The application of hyperbaric oxygenation (HBO2) has been recommended for correction of neurological injury in severely CO-poisoned patients. However, the mechanisms of HBO2 action on brain mitochondrial function under the circumstances is not yet understood completely. In the present study, the effect of HBO2 on the rat brain after CO exposure was evaluated by measuring the intramitochondrial NADH and its responses to anoxic test or repetitive induction spreading depression (SD) leading to brain activation. A unique monitoring system for bilateral monitoring of brain NADH redox state was used. Rats were exposed to 3000 ppm CO for 30 (group A) or 60 min (C). In groups B and D, after CO exposure, the rats were exposed to HBO2 (3 atm abs for 30 min). Following CO exposure in groups A and C, a definite decrease in the amplitude of the NADH response and significant increase in the number of waves of NADH was noted during induced cortical SD. Anoxic test in these two groups led to a significant decrease of maximum levels of NADH (reduction) at the end of observation. The amplitude, and the number of SD waves and magnitude of NADH deviation during anoxic test in group B after application of HBO2, was not significantly different from the values measured under the initial conditions. However, in group D, tendency of maintenance of the parameter's initial level was weaker or absent. The results obtained indicated that suppression of brain energy metabolism is a characteristic manifestation of CO poisoning in rats. Restoration of cerebral energy metabolism by adequate dosage of HBO2 may become an important factor for recovery of brain activities after CO poisoning.
Interrelation of cardiodynamics and pulmonary gas exchange in an experimental model of the acute respiratory failure syndrome.
Rogatsky G.G.
Laboratory of Experimental Pathology, Sklifosovsky Emergency Medicine Research Institute, Moscow.
Experiments were made on 30 dogs with lung contusion or injury to the chest wall. Eighteen animals demonstrated acute progressive arterial hypoxemia which proved to be fatal. Apart from the symptoms pointing to the development of gas exchange abnormalities, one could observe progressive impairment of myocardial function. A close correlation was established between pulmonary gas exchange and myocardial contractility. Myocardial dysfunction is regarded as one of the leading components in the pathogenesis of acute respiratory insufficiency in chest injury.
Use of hyperbaric oxygenation to correct an acute experimental respiratory insufficiency syndrome.
Rogatsky G.G., Vainshtein M.B., Sevost'ianova T.V.
Laboratory of Experimental Pathology, Sklifosovsky Emergency Medicine Research Institute, Moscow.
The results of the experiments on 159 Wistar rats have shown that one two-hour session of hyperbaric oxygenation (HBO) under the pressure of 3 ata affects considerably the course of acute respiratory insufficiency syndrome: the mortality rate decreases markedly, the development of arterial hypoxemia and structural changes peculiar to the "wet" lung could be averted. The results of the investigations demonstrate the possibility of HBO application for the prophylaxis and treatment of the syndrome.
Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats.
Krakovsky M., Rogatsky G., Zarchin N., Mayevsky A.
Department of Life Sciences, Bar-Ilan University, Ramat Gan, ISRAEL
BACKGROUND Hyperbaric oxygenation (HBO) has been considered for many years for the treatment of severe brain ischemia. However, its efficacy has not been proven. The aim of this study was to shed light on this question. METHODS Acute global cerebral ischemia was induced in 18 rats using the four-vessel occlusion model. Regional cerebral blood flow (CBF) was determined by laser-Doppler flowmetry using a flexible 1 mm fiberoptic probe. Two stainless steel screws were used to measure the spontaneous electrical activity from the contralateral hemisphere. After ischemia monitored by laser-Doppler flowmetry and ECoG, the animals were divided into two groups: (1) control animals that breathed air at atmospheric pressure and (2) rats exposed to HBO at three atmospheres absolute pressure (ATA) for 1 hour. Survival time and rate were recorded for both groups of animals for 14 days. RESULTS The survival rate in the study group was significantly higher (45%) than in the control group (0%). In the animals that did not survive the 14-day period, those exposed to HBO survived longer than the control animals (59.8 ± 9.1 hour versus 17.9 ± 2.7 hours, p < 0.05). CONCLUSION This investigation demonstrates that HBO administered after global cerebral ischemia can increase survival in a rat stroke model.
